The human tumour suppressor protein p53 is critical for regulation of the cell cycle on genotoxic insult. When DNA is damaged by radiation, chemicals or viral infection, cells respond rapidly by arresting the cell cycle. A G1 arrest requires the activity of wild‐type p53, as it is not observed in cells lacking functionally wild‐type protein, and at least some component of S phase and G2/M arrests is also thought to be p53‐dependent. p53 functions as a transcription factor which binds specific (...) DNA sequences, and recently major downstream targets have been identified, including p21Cip1 an inhibitor of the cell cycle kinases that also blocks the replicative but not the repair function of DNA polymerase δ auxiliary factor, PCNA. Current interest focuses on developing novel cancer therapies based on our knowledge of the activity of p53 and p21Cip1 in the cell cycle. (shrink)

Americans cherish the idea that good eventually triumphs over evil. After briefly arguing that a proper understanding of the moral harm of cruelty calls into question the credibility of popular American idioms of redemption, I argue that the epistemic dynamics of horror help account for the commanding grip of this rhetoric on the popular imagination, and I suggest that this idiom has morally problematic features that warrant the attention of feminists.

: Americans cherish the idea that good eventually triumphs over evil. After briefly arguing that a proper understanding of the moral harm of cruelty calls into question the credibility of popular American idioms of redemption, I argue that the epistemic dynamics of horror help account for the commanding grip of this rhetoric on the popular imagination, and I suggest that this idiom has morally problematic features that warrant the attention of feminists.

This volume is fourth in the series of annuals created under the auspices of The Association for Feminist Ethics and Social Theory . The topics covered herein_from peacekeeping and terrorism, to sex trafficking and women's paid labor, to poverty and religious fundamentalism_are vital to women and to feminist movements throughout the world.

What happens during a near-death experience? In an accessible style, this text reviews recent research about unbelievable events, creating an account of activity at the boundaries of science. It also examines research concerns, current theories, methodological issues and clinical implications.

Human flourishing is the topic of an increasing number of books and articles in educational philosophy. Flourishing should be regarded as an ideal aim of education. If this is defended, the first step should be to elucidate what is meant by flourishing, and what exactly the concept entails. Listing formal criteria can facilitate reflection on the ideal of flourishing as an aim of education. We took Aristotelian eudaimonia as a prototype to construct two criteria for the concept of human flourishing: (...) human flourishing is regarded as intrinsically worthwhile and flourishing means ‘actualisation of human potential’. The second criterion has three sub-criteria: flourishing is about a whole life, it is a ‘dynamic state’ and flourishing presupposes there being objective goods. (shrink)

Following the highly publicized New Bedford rape case, in which a young woman was raped by several men on a pool table in New Bedford, Massachusetts, on March 6, 1983, a segment of the local Portuguese community responded with great hostility to the rape victim and with sympathy for the rapists. The victim was blamed for the ethnic prejudice that erupted after the rape and culminated in the trial of six rapists in 1984. This article's purpose is to analyze the (...) Portuguese community's response, particularly the negative reactions of Portuguese women to another Portuguese woman who had been raped, and the conflict that developed between ethnic and sexual forms of prejudice. (shrink)

This article presents a computational model of the learning of diagnostic knowledge, based on observations of human operators engaged in real-world troubleshooting tasks. We present a model of problem solving and learning in which the reasoner introspects about its own performance on the problem-solving task, identifies what it needs to learn to improve its performance, formulates learning goals to acquire the required knowledge, and pursues its learning goals using multiple learning strategies. The model is implemented in a computer system which (...) provides a case study based on observations of troubleshooting operators and protocol analysis of the data gathered in the test area of an operational electronics manufacturing plant. The model not only addresses issues in human learning, but, in addition, is computationally justified as a uniform, extensible framework for multistrategy learning. (shrink)

This chapter contains sections titled: The correspondence view Accounting for the two theses Implications.

Gestures are a special sort of action. They communicate the individual's moods and desires to the world and they operate under different psychological and cognitive constraints to other actions. The connections between gesture and language - spoken and signed - pose some fascinating questions. How intimately are gesture and language connected? Did one evolve from the other? To what extent are they similarly processed in the brain? In what ways are signed languages akin to spoken language and gestures? Gesture, Speech, (...) and Sign examines these questions, bringing together an international array of expertise to explore the origins, neurobiology, and uses of these three communication systems. A unique feature of the book is its discussion of how a greater understanding of these issues can be used to improve human-computer interactions. Designed to appeal to a multi-disciplinary audience Gesture, Speech, and Sign will be of interest to advanced students and researchers in neuroscience, psychology, linguistics, computer science, and those involved in deaf studies. (shrink)

The philosopher Donald Davidson has argued in an influential article, “On the Very Idea of a Conceptual Scheme,” that there is no intelligible basis on which to distinguish between conceptual schemes that Kuhn and Feyerabend have treated as incommensurable or incompatible. He concludes that, given the underlying methodology of interpretation of speech behavior, we cannot be in a position to judge that others have concepts or beliefs radically different from our own. Thus, he adds, we cannot talk meaningfully about the (...) existence of conceptual schemes. I offer a historical rejoinder to Davidson, focusing on the famous seventeenth-century debate between Descartes and Gassendi regarding the use of the first-person pronoun. I show that, in this particular debate, their failure to translate the pronoun “I” was so basic and fundamental a failure that, although it turned on just one word, it forced Gassendi to question the longstanding Renaissance humanist principle of the intertranslatability of all natural languages. Could the Gassendi-Descartes debate similarly challenge Davidson’s assertion of the intertranslatability of all natural languages and his consequent denial of the existence of conceptual schemes? (shrink)

(1996). Photomechanical tendencies in Giorgio de Chirico's Melancholy vision. The European Legacy: Vol. 1, Fourth International Conference of the International Society for the Study of European Ideas, pp. 1310-1315.

Although the overwhelming majority of terminally ill patients in Oregon who seek a physician's aid in dying are enrolled in hospice programs, hospices do not take a major role in this practice. An examination of fifty‐five Oregon hospices reveals that both legal and moral questions prevent hospices from collaborating fully with physician‐assisted death.